AMN Information

If the gene becomes active in adulthood, the disease is knows as Adrenomyelonueropathy(AMN). Men that experience AMN also endure demyelination, however, it most commonly restricts itself to the long tracts of the spinal column causing increasing difficulty with walking, as well as bladder and bowel disturbances over a period of decades. Approximately one third of the men who develop AMN, demyelination of the brain does take place, with a much more debilitating effect.

70% of AMN patients experience Addison's Disease. There is also an Addison's-only form of the disease that appears to spare the nervous system. Many, but not all of the Addison's-only patients develop AMN characteristics later in life.