ALD Foundation - Information on ALD, AMN and Addison's Disease.  Click here to return to our home page.
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Educational Material

ALD
Adrenoleukodystrophy, or ALD, is a genetically determined neurological disorder that affects 1 in every 17,900 boys worldwide. The presentation of symptoms occurs between the ages of 4 and 10, and affects the brain with demyelination.
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AMN
If the gene becomes active in adulthood, the disease is knows as Adrenomyelonueropathy(AMN). Men that experience AMN also endure demyelination, however, it most commonly restricts itself to the long tracts of the spinal column causing increasing difficulty with walking, as well as bladder and bowel disturbances over a period of decades. Approximately one third of the men who develop AMN, demyelination of the brain does take place, with a much more debilitating effect.
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Addison's Disease
Addison's disease is an endocrine or hormonal disorder that occurs in all age groups and afflicts men and women equally. The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and sometimes darkening of the skin in both exposed and non exposed parts of the body.
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Carriers
Approximately 40% of X-ALD heterozygotes (female carriers) develop neurological symptoms similar to those encountered by AMN patients. Age of symptoms for the heterozygotes is late 30's to 40's. It is also worth noting that patients presenting in Neurology Clinic for investigation of M. S. like symptoms. Adrenal function is almost always normal.
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Clinical Trials / Studies
View current clinical trials and studies concerning ALD, AMN and Addison's Disease. Contact information is available for interested participants or those seeking more detailed information.
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Links
Learn more about ALD, AMN and Addison's Disease by visiting such organizations as The Myelin Project and The STOPALD Foundation.
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